Alpha Lipoic Acid 600mg | DL-ALA | Universal Antioxidant and Glucose Metabolism | Mitochondrial Cofactor | 120 Vegan Capsules

Each vegan capsule delivers 600mg of DL-alpha-lipoic acid (50% R-ALA, 50% S-ALA). A universal antioxidant active in both aqueous and lipid cellular environments, an antioxidant network regenerator, and an essential mitochondrial enzyme cofactor. Antioxidant. Helps support glucose metabolism. A factor in the maintenance of good health.

Source

Form: DL-alpha-lipoic acid, the racemic 50:50 mixture of R-ALA (naturally occurring mitochondrial enantiomer) and S-ALA (synthetic enantiomer).
Production: Synthetically produced. Not derived from animal sources. Suitable for vegans and vegetarians.
R-ALA content: Approximately 300mg of biologically active R-ALA per 600mg capsule.
Why DL-ALA: More chemically stable than pure R-ALA and the most widely studied form in clinical research.

What Is Alpha Lipoic Acid?

Alpha-lipoic acid (ALA) is a sulfur-containing fatty acid with two distinct biological roles. Endogenously, it is covalently bound to mitochondrial enzyme complexes as an essential cofactor for energy metabolism. At supplemental doses, free ALA functions as a universal antioxidant active in both aqueous and lipid environments, and supports glucose metabolism via AMPK activation. ALA is reduced to dihydrolipoic acid (DHLA) by lipoamide dehydrogenase, and the ALA/DHLA redox couple drives its antioxidant network activity.

What Makes ALA a Universal Antioxidant?

Most antioxidants are limited to one environment: vitamin C works in aqueous (water-based) compartments, vitamin E works in lipid (fat-based) membranes. ALA and its reduced form DHLA are active in both, allowing a single molecule to protect water-soluble and fat-soluble cellular components simultaneously. DHLA also regenerates vitamin C, vitamin E, and glutathione, extending the antioxidant activity of the entire network.

Key Benefits

• Antioxidant Health Canada licensed claim under NPN 80122537 | Active in both aqueous and lipid cellular environments
• Helps support glucose metabolism Health Canada licensed claim | AMPK activation promotes GLUT4 translocation and insulin-stimulated glucose uptake
• A factor in the maintenance of good health Health Canada licensed claim under NPN 80122537
• Antioxidant network regeneration DHLA regenerates vitamin C, vitamin E, and glutathione
• Metal ion chelation Binds copper, iron, cadmium, and mercury, reducing Fenton reaction-driven free radical generation
• Mitochondrial enzyme cofactor Essential for pyruvate dehydrogenase complex (PDC) and alpha-ketoglutarate dehydrogenase complex (KGDC)
• Source: synthetically produced DL-ALA 50% R-ALA, 50% S-ALA | Vegan, not animal derived
• Health Canada licensed NPN 80122537 | GMP certified | Third-party lab tested | Made in Canada
• 120 vegan capsules 120 day supply at 1 capsule per day

How It Works

The ALA/DHLA Redox Couple

ALA is reduced to DHLA by lipoamide dehydrogenase. The ALA/DHLA redox couple is active in both aqueous and lipid environments, unlike vitamin C (aqueous only) or vitamin E (lipid only). DHLA directly scavenges reactive oxygen species and drives the antioxidant network regeneration cascade: DHLA reduces dehydroascorbate back to vitamin C, vitamin C reduces the tocopheroxyl radical back to vitamin E, and DHLA reduces oxidized glutathione (GSSG) back to reduced glutathione (GSH).

Metal Ion Chelation

ALA and DHLA chelate pro-oxidant metal ions including copper, iron, cadmium, and mercury. Free iron and copper catalyze the Fenton reaction, converting hydrogen peroxide into highly reactive hydroxyl radicals. By binding these metals, ALA reduces their ability to generate free radicals, providing an additional antioxidant mechanism beyond direct radical scavenging.

Mitochondrial Cofactor Role

Endogenously, ALA is covalently bound to the E2 subunit of two critical mitochondrial enzyme complexes. The pyruvate dehydrogenase complex (PDC) converts pyruvate to acetyl-CoA, linking glycolysis to the citric acid cycle. The alpha-ketoglutarate dehydrogenase complex (KGDC) catalyzes a key step within the citric acid cycle. ALA is essential for both reactions.

Glucose Metabolism: AMPK and GLUT4

At supplemental doses, free ALA activates AMPK (AMP-activated protein kinase), promoting GLUT4 glucose transporter translocation to the cell surface in muscle and adipose tissue and enhancing insulin-stimulated glucose uptake. This glucose-lowering effect is the basis for the diabetes caution and the mandatory hypoglycemia stop-use warning.

Medicinal Ingredient (per capsule)

• DL-alpha-Lipoic Acid 600mg 50% R-ALA (approximately 300mg), 50% S-ALA | Synthetically produced | Antioxidant | Helps support glucose metabolism | A factor in the maintenance of good health | NPN 80122537

Non-medicinal ingredients: Hypromellose (vegetable capsule shell), microcrystalline cellulose, silicon dioxide. No artificial colours, flavours, sweeteners, or preservatives. Vegan. Gluten free. Soy free. Dairy free. Corn free. Non-GMO.

Quality and Trust

• NPN 80122537 Licensed by Health Canada as a Natural Health Product
• Made in Canada GMP certified facility under Health Canada oversight
• Third-party lab tested Purity and potency independently verified
• Source: synthetically produced DL-ALA Vegan, not animal derived
• Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
• 100% vegan, non-GMO, gluten free, soy free, dairy free, corn free
• 120 vegan capsules 120 day supply at 1 capsule per day

Who This Is For

• Stop use and consult a healthcare practitioner if you experience sweating, paleness, chills, headache, dizziness, or confusion — these may be symptoms of serious low blood sugar
• Consult a healthcare practitioner before use if you have diabetes or are taking antidiabetic medications, or if you are pregnant or breastfeeding
• Adults seeking a universal antioxidant that regenerates vitamin C, vitamin E, and glutathione and is active in both aqueous and lipid environments
• Those seeking glucose metabolism support from a mitochondrial cofactor with AMPK-activating activity
• Vegans and vegetarians seeking a synthetically produced, non-animal-derived ALA supplement

How to Use

Adults: Take 1 capsule, 1 time per day, or as directed by a healthcare practitioner. Store in a cool, dry place away from direct sunlight. Keep bottle tightly sealed ALA is sensitive to heat and light.

Safety and Cautions

Consult a healthcare practitioner before use if you have diabetes or are taking antidiabetic medications, or if you are pregnant or breastfeeding. Store in a cool, dry place away from direct sunlight. Keep bottle tightly sealed. Do not use if the seal is broken or missing. Keep out of reach of children.

NPN 80122537. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.