L-Citrulline 750mg | Circulation and Nitric Oxide Support | Free Form Amino Acid | 120 Vegan Capsules

Why Customers Choose This Formula

• 750mg pure free form L-citrulline per capsule Non-essential amino acid | Precursor to L-arginine and nitric oxide in the body
• Supports healthy circulation Via the L-citrulline to L-arginine to nitric oxide pathway
• Supports exercise performance and muscle recovery As part of a balanced diet and active lifestyle
• Health Canada licensed NPN 80139498
• Vegan capsules Hypromellose shell, no gelatin
• Non GMO | Gluten free | Soy free
• Made in Canada GMP certified facility under Health Canada oversight
• 120 capsules 30 day supply at the recommended 4 capsules per day (2 capsules twice daily)

What This Is

L-Citrulline 750mg provides 750mg of pure free form L-citrulline per capsule, a non-essential amino acid that serves as a precursor to L-arginine and nitric oxide in the body. L-citrulline is absorbed intact from the gastrointestinal tract and converted to L-arginine in the kidneys, supporting sustained L-arginine availability and nitric oxide production. This formula is licensed by Health Canada with NPN 80139498, manufactured in Canada to GMP standards, and independently tested for purity and potency. This product is intended for proactive wellness support and is not a substitute for medical care.

The Science

What Is L-Citrulline?

L-citrulline is a non-essential amino acid first isolated from watermelon (Citrullus vulgaris) in 1930, which remains one of the richest natural food sources of L-citrulline (approximately 250mg per cup of watermelon flesh). L-citrulline plays a central role in the urea cycle, the metabolic pathway responsible for converting ammonia to urea for excretion, and serves as a key precursor to L-arginine. Unlike L-arginine, which undergoes significant first pass metabolism in the intestinal wall and liver, L-citrulline is absorbed intact and converted to L-arginine primarily in the kidneys, resulting in more sustained and efficient elevation of plasma L-arginine levels compared to direct L-arginine supplementation.

L-Citrulline, L-Arginine, and Nitric Oxide

L-arginine is the substrate for nitric oxide synthase (NOS), the enzyme responsible for producing nitric oxide (NO) from L-arginine and oxygen. Nitric oxide is a gaseous signaling molecule that plays a central role in vascular function, acting as a potent vasodilator by relaxing vascular smooth muscle and supporting healthy blood vessel tone and circulation. By serving as a precursor to L-arginine, L-citrulline supports the body's nitric oxide production pathway and healthy circulation. This is the basis for L-citrulline's use in supporting exercise performance and cardiovascular wellness as part of an active lifestyle.

Why L-Citrulline Rather Than L-Arginine?

L-arginine supplementation is limited by significant first pass metabolism in the intestinal wall and liver, where the enzyme arginase rapidly degrades L-arginine before it reaches systemic circulation. This limits the bioavailability of oral L-arginine supplementation. L-citrulline bypasses this limitation because it is not a substrate for arginase and is absorbed intact, converting to L-arginine in the kidneys where it enters systemic circulation. Research comparing oral L-citrulline to oral L-arginine demonstrates that L-citrulline supplementation produces greater and more sustained increases in plasma L-arginine levels than equivalent doses of L-arginine itself.

L-Citrulline and Exercise Performance

L-citrulline supports exercise performance through its role in nitric oxide production and the urea cycle. By supporting nitric oxide production, L-citrulline supports healthy circulation to working muscles during exercise. By supporting urea cycle function, L-citrulline supports the clearance of ammonia, a metabolic byproduct of amino acid catabolism that accumulates during intense exercise and contributes to fatigue. L-citrulline is commonly used by athletes and active individuals as part of a pre-workout or daily amino acid supplementation routine to support exercise performance and muscle recovery as part of a balanced diet and active lifestyle.

Medicinal Ingredient (per capsule)

• L-Citrulline (free form) 750mg Non-essential amino acid | Precursor to L-arginine and nitric oxide | Supports healthy circulation and exercise performance | NPN 80139498

Non medicinal ingredients: Hypromellose (vegetable capsule shell), microcrystalline cellulose, magnesium stearate.

Quality and Trust

• NPN 80139498 Licensed by Health Canada as a Natural Health Product
• Made in Canada GMP certified facility under Health Canada oversight
• Third party tested Purity and potency independently verified
• 750mg pure free form L-citrulline per capsule 3,000mg per daily dose of 4 capsules
• Vegan capsules Hypromellose shell, no gelatin
• Non GMO | Gluten free | Soy free
• 120 capsules 30 day supply at 4 capsules per day

Who This Is For

• Athletes and active adults seeking circulation and exercise performance support from a Health Canada licensed free form L-citrulline supplement
• Those who prefer L-citrulline over L-arginine for its superior bioavailability and more sustained plasma L-arginine elevation
• Health conscious consumers who prefer a clean, vegan, non GMO, Canadian made amino acid supplement with no artificial additives

How to Use

Adults: Take 2 capsules 2 times per day. At 4 capsules per day, one bottle of 120 capsules provides a 30 day supply. Can be taken with or without food. Commonly taken before exercise for circulation and performance support.

Safety and Cautions

Ask a healthcare practitioner before use if you are taking medication for cardiovascular diseases, erectile dysfunction, or blood thinners. Ask a healthcare practitioner before use if you have a cardiovascular disease and are attempting an increase in physical activity. Ask a healthcare practitioner before use if you are pregnant or breastfeeding. Keep out of reach of children. Store in a cool, dry place away from direct sunlight and moisture. Do not use if the seal is broken or missing.

NPN 80139498. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.