Silymarin as supportive treatment in liver diseases: a narrative review
Advances in Therapy, 2020
Each vegan capsule delivers 600mg of Silybum marianum seed extract standardized to 80% silymarin the concentrated flavonolignan complex responsible for milk thistle's hepatoprotective activity. Traditionally used in herbal medicine as a hepatoprotectant and liver protectant. Used in herbal medicine to help support liver function.
This 2 Pack contains 2 × 120 vegan capsules (240 capsules total). Better per-capsule value for consistent, long-term daily liver support.
Milk thistle (Silybum marianum) is a flowering herb in the Asteraceae family native to the Mediterranean region and naturalized worldwide. It has been used in traditional European herbal medicine for over 2,000 years as a liver and gallbladder remedy. The medicinal activity of milk thistle is concentrated in the seed, which contains silymarin a complex of flavonolignans including silybin (the most biologically active component), silydianin, and silychristin. Silymarin is standardized in this formula to 80% of the extract weight, providing 480mg of silymarin per 600mg capsule a consistent, high-potency dose aligned with the clinical research literature on milk thistle hepatoprotection.
Silymarin exerts hepatoprotective activity through multiple mechanisms: it stabilizes hepatocyte cell membranes by altering their surface structure to prevent toxin penetration; it acts as an antioxidant by scavenging free radicals and inhibiting lipid peroxidation in liver tissue; it stimulates ribosomal RNA synthesis to support hepatocyte regeneration; and it inhibits the binding of toxins to hepatocyte membrane receptors. These combined mechanisms underlie milk thistle's traditional and evidence informed use as a hepatoprotectant.
Silybin (also called silibinin) is the most abundant and most biologically active component of the silymarin complex, accounting for approximately 50–70% of silymarin by weight. It is the primary contributor to milk thistle's antioxidant and hepatoprotective activity and the component most extensively studied in clinical research.
Non-standardized milk thistle products may contain highly variable amounts of silymarin depending on the plant source, growing conditions, and extraction method. Standardization to 80% silymarin ensures that each 600mg capsule delivers a consistent 480mg of the active flavonolignan complex the same potency in every capsule, every bottle.
Milk thistle is most effective with consistent, long-term daily use. The 2 Pack provides 240 capsules, ensuring uninterrupted daily supplementation without frequent reordering. The 2 Pack format offers better per-capsule value compared to purchasing two single bottles separately, making consistent liver support more economical for established users.
Adults: Take 1 capsule once per day, or as directed by a healthcare practitioner. May be taken with or without food.
Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone-sensitive condition (milk thistle may have mild estrogenic activity), have a known allergy to Asteraceae/Compositae family plants (ragweed, chrysanthemums, marigolds, daisies), or are taking prescription medications including immunosuppressants or medications metabolized by the liver. Gastrointestinal upset may occur in sensitive individuals. Store in a cool, dry place. Keep out of reach of children. NPN 80086006.
Each vegan capsule delivers 600mg of Silybum marianum seed extract standardized to 80% silymarin the concentrated flavonolignan complex responsible for milk thistle's hepatoprotective activity. Traditionally used in herbal medicine as a hepatoprotectant and liver protectant. Used in herbal medicine to help support liver function.
This 2 Pack contains 2 × 120 vegan capsules (240 capsules total). Better per-capsule value for consistent, long-term daily liver support.
Milk thistle (Silybum marianum) is a flowering herb in the Asteraceae family native to the Mediterranean region and naturalized worldwide. It has been used in traditional European herbal medicine for over 2,000 years as a liver and gallbladder remedy. The medicinal activity of milk thistle is concentrated in the seed, which contains silymarin a complex of flavonolignans including silybin (the most biologically active component), silydianin, and silychristin. Silymarin is standardized in this formula to 80% of the extract weight, providing 480mg of silymarin per 600mg capsule a consistent, high-potency dose aligned with the clinical research literature on milk thistle hepatoprotection.
Silymarin exerts hepatoprotective activity through multiple mechanisms: it stabilizes hepatocyte cell membranes by altering their surface structure to prevent toxin penetration; it acts as an antioxidant by scavenging free radicals and inhibiting lipid peroxidation in liver tissue; it stimulates ribosomal RNA synthesis to support hepatocyte regeneration; and it inhibits the binding of toxins to hepatocyte membrane receptors. These combined mechanisms underlie milk thistle's traditional and evidence informed use as a hepatoprotectant.
Silybin (also called silibinin) is the most abundant and most biologically active component of the silymarin complex, accounting for approximately 50–70% of silymarin by weight. It is the primary contributor to milk thistle's antioxidant and hepatoprotective activity and the component most extensively studied in clinical research.
Non-standardized milk thistle products may contain highly variable amounts of silymarin depending on the plant source, growing conditions, and extraction method. Standardization to 80% silymarin ensures that each 600mg capsule delivers a consistent 480mg of the active flavonolignan complex the same potency in every capsule, every bottle.
Milk thistle is most effective with consistent, long-term daily use. The 2 Pack provides 240 capsules, ensuring uninterrupted daily supplementation without frequent reordering. The 2 Pack format offers better per-capsule value compared to purchasing two single bottles separately, making consistent liver support more economical for established users.
Adults: Take 1 capsule once per day, or as directed by a healthcare practitioner. May be taken with or without food.
Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone-sensitive condition (milk thistle may have mild estrogenic activity), have a known allergy to Asteraceae/Compositae family plants (ragweed, chrysanthemums, marigolds, daisies), or are taking prescription medications including immunosuppressants or medications metabolized by the liver. Gastrointestinal upset may occur in sensitive individuals. Store in a cool, dry place. Keep out of reach of children. NPN 80086006.
Serving Size: 1 Capsule
Servings Per Container: 120
† Daily Value not established
Advances in Therapy, 2020
Drugs, 2001
Digestive and Liver Disease, 2002
Research information is provided for educational purposes and does not replace the product's approved label information.