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Nattokinase 100 mg provides 2,000 fibrinolytic units (FU) per delayed-release vegan capsule. Made through fermentation with Bacillus subtilis var. natto, this formula is standardized to 20,000 FU per gram. The 60-capsule bottle provides a 60-day supply at one capsule daily.

What Is Nattokinase?

Nattokinase is an enzyme associated with natto, a traditional fermented soybean food. This product is derived from soy and uses nattokinase produced by Bacillus subtilis var. natto.

100 mg and 2,000 FU

Milligrams measure ingredient weight; fibrinolytic units measure enzyme activity. Each capsule contains 100 mg of nattokinase standardized to 20,000 FU per gram, providing 2,000 FU per capsule.

Delayed-Release Vegan Capsule

The nattokinase is provided in a delayed-release hypromellose capsule. Each bottle contains 60 capsules.

Nattokinase 100 mg, 2,000 FU | Delayed Release Vegan Capsules | 60 Count

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Health Canada Licensed Natural Health Product (NPN 80135521)

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Nattokinase 100 mg provides 2,000 fibrinolytic units (FU) per delayed-release vegan capsule. Made through fermentation with Bacillus subtilis var. natto, this formula is standardized to 20,000 FU per gram. The 60-capsule bottle provides a 60-day supply at one capsule daily.

What Is Nattokinase?

Nattokinase is an enzyme associated with natto, a traditional fermented soybean food. This product is derived from soy and uses nattokinase produced by Bacillus subtilis var. natto.

100 mg and 2,000 FU

Milligrams measure ingredient weight; fibrinolytic units measure enzyme activity. Each capsule contains 100 mg of nattokinase standardized to 20,000 FU per gram, providing 2,000 FU per capsule.

Delayed-Release Vegan Capsule

The nattokinase is provided in a delayed-release hypromellose capsule. Each bottle contains 60 capsules.

Supplement Facts

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 60

Other Ingredients:
Hypromellose (Delayed Release Vegetable Capsule Shell), Microcrystalline Cellulose, Magnesium Stearate

Clinical Research

Nattokinase: a promising alternative in prevention and treatment of cardiovascular diseases

Biomarkers in Medicine, 2017

This comprehensive review examined the clinical and preclinical evidence for nattokinase in cardiovascular health. The review found that nattokinase exerts fibrinolytic activity by directly cleaving fibrin and activating endogenous plasminogen, supporting healthy blood flow and vascular function. The authors documented evidence for nattokinase's effects on blood pressure, blood viscosity, and vascular health markers across multiple human and animal studies

Effects of nattokinase on blood pressure: a randomized, controlled trial

Hypertension Research, 2008

This randomized, double blind, placebo controlled trial administered nattokinase to subjects with pre hypertension and stage 1 hypertension over 8 weeks and measured blood pressure and vascular health markers. The study found that nattokinase supplementation significantly reduced systolic and diastolic blood pressure compared to placebo, with the effect attributed to nattokinase's fibrinolytic activity and its effects on vascular tone and blood flow. The findings support nattokinase's role in cardiovascular and vascular health support

Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects

Nutrition Research, 2009

This randomized, double blind, placebo controlled trial administered nattokinase supplementation to healthy human subjects and measured coagulation factors and blood flow markers over the study period. The study found that nattokinase significantly decreased plasma levels of fibrinogen, factor VII, and factor VIII key proteins involved in blood clot formation compared to placebo.

Research information is provided for educational purposes and does not replace the product's approved label information.

Frequently Asked Questions

What is nattokinase and what is it used for?

Nattokinase is a serine protease enzyme derived from natto a traditional Japanese fermented food made from soybeans fermented with Bacillus subtilis var. natto. First isolated in 1987, nattokinase is characterized by its fibrinolytic activity its ability to act directly on fibrin, the protein that forms the structural scaffold of blood clots. Nattokinase is licensed by Health Canada for cardiovascular health support. Do not use if you have a soy allergy, a bleeding disorder, or are taking medications that affect blood coagulation.

What are fibrinolytic units (FU) and why do they matter?

Fibrinolytic units (FU) measure nattokinase enzyme activity specifically, its ability to break down fibrin. FU is the internationally standardized potency measure established by the Japan Nattokinase Association. Two nattokinase products with the same milligram dose can have very different potencies depending on their FU standardization. A product standardized to 20,000 FU per gram delivers 2,000 FU from 100mg per capsule. When comparing nattokinase supplements, always compare FU not milligrams alone.

What is natto and why is it the best source of MK-7?

Natto is a traditional Japanese fermented food made from soybeans and is the richest known dietary source of menaquinone-7 (MK-7). Natto has been consumed in Japan for over a thousand years and is the food source from which MK-7 was first identified and characterized. MK-7 derived from natto is 100% plant based, making it suitable for vegans and vegetarians. Soy protein is removed during extraction consult a healthcare practitioner if you have a severe soy allergy.

Does nattokinase contain soy or allergens?

Yes. Nattokinase is derived from the fermentation of soybeans withBacillus subtilisvar.natto. Do not use if you have a soy allergy. The capsule shell is vegan hypromellose no gelatin. Non-medicinal ingredients: Hypromellose (Delayed Release Vegetable Capsule Shell), Microcrystalline Cellulose, Magnesium Stearate (Vegetable Source). Non-GMO. Gluten free. Suitable for vegans and vegetarians with no soy allergy.

Who should not take nattokinase?

Do not use if you are pregnant or breastfeeding, taking health products that affect blood coagulation (anticoagulants, antiplatelet drugs), or have a bleeding disorder. Do not use if you have a soy allergy this product is derived from fermented soy (Bacillus subtilisvar.natto). Stop use 7 days before any scheduled surgery, or immediately if you have unscheduled surgery or suffer an injury resulting in bruising or bleeding. Consult a healthcare practitioner before use if you have a cardiovascular, kidney, or liver disorder.

Can I take nattokinase if I am on blood thinners?

No. Do not use if you are taking health products that affect blood coagulation including anticoagulants such as warfarin or antiplatelet drugs. Nattokinase has fibrinolytic enzymatic activity and may enhance the effects of blood thinning medications, increasing the risk of bleeding. Consult a healthcare practitioner before use if you have a cardiovascular disorder or are taking any medications. Stop use 7 days before any scheduled surgery.

Should I take nattokinase with food or on an empty stomach?

Take 1 capsule on an empty stomach or between meals. Taking on an empty stomach maximizes intestinal transit time and reduces competition from dietary proteins for enzymatic activity. The delayed release capsule protects the enzyme from stomach acid regardless of food intake, but taking between meals is generally recommended for enzyme supplements. For use beyond 4 weeks, consult a healthcare practitioner.

How does nattokinase support cardiovascular health?

Nattokinase is a serine protease enzyme with fibrinolytic activity it cleaves fibrin, the protein scaffold of blood clots. It has been studied for its effects on blood flow, vascular function, and cardiovascular health markers. Licensed by Health Canada to support cardiovascular health, vascular health, and healthy blood flow. Consult a healthcare practitioner before use if you have a cardiovascular disorder or are taking any medications. Do not use if taking anticoagulants or antiplatelet drugs.