Medicinal Ingredient (per 1 capsule)
Nattokinase………………………..100mg
(Bacillus subtilis var. natto – Whole; 20,000FU/g)

Non-Medicinal Ingredients
Hypromellose, Microcrystalline Cellulose, Magnesium Stearate

Recommended Dosage
Adults: 1 capsule 1 time per day.

Duration of Use
For use beyond 4 weeks, consult a health care practitioner.

Cautions and Warnings
This product is derived from soy. Do not use if you have soy allergy.
Consult a health care practitioner if you have a cardiovascular, kidney, or liver disorder, or if you are taking any medications.
Stop using this product 7 days before any scheduled surgery, or immediately if you have unscheduled surgery or if you suffer from an injury resulting in bruising or bleeding.

Contraindications
Do not use if you are pregnant or breastfeeding, if you are taking health products that affect blood coagulation, or if you have a bleeding disorder.

Q1: What is Nattokinase 100mg 2000 FU?
Nattokinase 100mg 2000 FU provides 100mg of nattokinase (Bacillus subtilis var. natto, whole) per delayed release vegan capsule, standardized to 20,000 FU per gram, delivering 2,000 fibrinolytic units per capsule. Licensed by Health Canada with NPN 80135521 for cardiovascular health support, manufactured in Canada to GMP standards under the Nutridom brand. 60 capsules, 60 day supply at 1 capsule per day. This product is derived from soy. Do not use if you have a soy allergy.

Q2: What is nattokinase and where does it come from?
Nattokinase is a serine protease enzyme produced during the fermentation of soybeans by Bacillus subtilis var. natto, the bacterial culture used to produce natto, a traditional Japanese fermented soybean food. It was first isolated in 1987 by Dr. Hiroyuki Sumi, who identified its fibrinolytic activity. Nattokinase acts on fibrin, the protein that forms the structural scaffold of blood clots, and is licensed by Health Canada for cardiovascular health support.

Q3: What are fibrinolytic units (FU) and why do they matter?
Fibrinolytic units (FU) measure nattokinase enzyme activity, not weight. Two nattokinase products with the same milligram dose can have very different potencies depending on their FU standardization. FU is the internationally standardized measure of nattokinase activity established by the Japan Nattokinase Association, quantifying the rate at which the enzyme dissolves a fibrin substrate under defined laboratory conditions. This formula is standardized to 20,000 FU per gram, delivering 2,000 FU from 100mg per capsule. When comparing nattokinase supplements, always compare FU, not milligrams alone.

Q4: What is the licensed use of this product?
This formula is licensed by Health Canada (NPN 80135521) for cardiovascular health support. This is the licensed recommended use as approved under Health Canada's Natural Health Products Regulations.

Q5: Why is this formula in a delayed release capsule?
Nattokinase is a protein based enzyme. Proteins are broken down by stomach acid and pepsin before they reach the small intestine. A standard capsule releases its contents into the stomach, where the enzyme can be degraded before absorption. This formula uses a delayed release hypromellose capsule designed to remain intact in the acidic stomach environment and dissolve only at the higher pH of the small intestine, where the enzyme reaches the site of absorption with its biological activity preserved. This is a delivery decision made specifically for enzyme stability, not a marketing feature.

Q6: Who should not take this product?
Do not use if you have a soy allergy (this product is derived from soy), if you are pregnant or breastfeeding, if you are taking health products that affect blood coagulation (including blood thinners, anticoagulants, antiplatelet medications, or other natural health products with blood coagulation effects), or if you have a bleeding disorder. These are absolute contraindications, not recommendations to consult a healthcare practitioner.

Q7: Is there a surgery warning for this product?
Yes. Stop use 7 days before any scheduled surgery. If you have unscheduled surgery or suffer an injury resulting in bruising or bleeding, stop use immediately. This is a Health Canada licensed caution for NPN 80135521 and applies to all users regardless of dose or duration of use.

Q8: Who should consult a healthcare practitioner before use?
Consult a healthcare practitioner before use if you have a cardiovascular, kidney, or liver disorder, or if you are taking any medications. For use beyond 4 weeks, consult a healthcare practitioner. If you are unsure whether nattokinase is appropriate for you given your health status or medications, speak with your healthcare practitioner before purchasing.

Q9: How long can this product be used?
For use beyond 4 weeks, consult a healthcare practitioner. This is a Health Canada licensed duration of use restriction for NPN 80135521.

Q10: How do I take Nattokinase 100mg 2000 FU?
Adults: Take 1 capsule once daily. One bottle of 60 capsules provides a 60 day supply. For use beyond 4 weeks, consult a healthcare practitioner. Stop use 7 days before any scheduled surgery.

Q11: Is this product derived from soy?
Yes. Nattokinase is produced by fermenting soybeans with Bacillus subtilis var. natto. This product is derived from soy and must not be used by anyone with a soy allergy.

Q12: Is this product licensed by Health Canada?
Yes. Nattokinase 100mg 2000 FU is a licensed Natural Health Product approved by Health Canada under the Natural Health Products Regulations with NPN 80135521. It is manufactured in a GMP certified facility in Canada.