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Nattokinase 2000 FU delayed release enzyme supplement 120 vegan capsules
Nattokinase 2000 FU delayed release supplement capsules
Nattokinase enzyme supplement delayed release vegan capsules
Nattokinase 2000 FU daily wellness supplement 120 capsules
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Nattokinase 2000 FU delayed release enzyme supplement 120 vegan capsules

Nattokinase 2000 FU | Delayed Release | Cardiovascular & Vascular Health | 120 Vegan Capsules

Each delayed release vegan capsule delivers 100mg of nattokinase providing 2,000 Fibrinolytic Units (FU) of enzymatic activity, standardized to 20,000 FU/g. Nattokinase is a serine protease enzyme produced during the fermentation of soybeans with Bacillus subtilis var. natto the same fermentation process used to produce natto, a traditional Japanese food consumed for over 1,000 years. Supports cardiovascular health, vascular health, and healthy blood flow.

Delayed release capsule technology protects the enzyme from stomach acid degradation, ensuring delivery to the intestines where absorption occurs. Health Canada licensed NPN 80135521. Vegan. Non-GMO. Gluten free. Made in Canada. 120 vegan capsules 120 day supply at 1 capsule per day.

Key Benefits

  • Supports cardiovascular health — Health Canada licensed claim under NPN 80135521
  • Supports vascular health — Health Canada licensed claim under NPN 80135521
  • Supports healthy blood flow — Health Canada licensed claim under NPN 80135521
  • 2,000 FU nattokinase per capsule — From 100mg nattokinase standardized to 20,000 FU/g
  • Delayed release capsule — Protects the enzyme from stomach acid | Delivers nattokinase intact to the intestines for optimal absorption
  • Serine protease enzyme — Produced by Bacillus subtilis var. natto fermentation of soybeans
  • Vegan capsule — Hypromellose delayed release shell, no gelatin or animal derived ingredients
  • Health Canada licensed — NPN 80135521 | GMP certified | Made in Canada
  • 120 vegan capsules — 120 day supply at 1 capsule per day

What Is Nattokinase?

Nattokinase is a serine protease enzyme produced during the fermentation of soybeans with Bacillus subtilis var. natto. It was first isolated and characterized by Dr. Hiroyuki Sumi in 1987 while researching natural fibrinolytic compounds. Natto the fermented soybean food from which nattokinase is derived has been consumed in Japan for over 1,000 years and is a traditional component of the Japanese diet.

Nattokinase enzymatic activity is measured in Fibrinolytic Units (FU), a standardized measure of the enzyme's proteolytic activity. This formula provides 2,000 FU per capsule from 100mg of nattokinase standardized to 20,000 FU/g a consistent, high-activity dose aligned with the clinical research literature.

Why Delayed Release Capsules Matter for Nattokinase

Nattokinase is a protein-based enzyme. Like all proteins, it is susceptible to denaturation and degradation in the highly acidic environment of the stomach (pH 1.5 to 3.5). Standard capsules release their contents immediately in the stomach, exposing the enzyme to acid before it can reach the intestines where absorption occurs.

Delayed release (enteric) capsules are engineered to remain intact in the acidic stomach environment and dissolve only when they reach the higher pH of the small intestine (pH 5.5 to 7.5). This protects the nattokinase enzyme from acid degradation and ensures delivery to the intestinal environment where it can be properly absorbed a critical distinction for enzyme supplements.

Understanding Fibrinolytic Units (FU)

FU (Fibrinolytic Units) is the standardized measure of nattokinase enzymatic activity. It quantifies the enzyme's ability to cleave fibrin the protein that forms the structural scaffold of blood clots. Higher FU indicates greater enzymatic activity per unit of enzyme. This formula provides:

  • Nattokinase per capsule: 100mg
  • Standardized potency: 20,000 FU/g
  • Activity per capsule: 2,000 FU
  • Daily dose: 1 capsule per day = 2,000 FU

Medicinal Ingredient (per capsule)

  • Nattokinase (Bacillus subtilis var. natto, whole) 100mg Standardized to 20,000 FU/g | 2,000 FU per capsule | Cardiovascular health | Vascular health | Healthy blood flow | NPN 80135521

Non-medicinal ingredients: Hypromellose (delayed release vegetable capsule shell), microcrystalline cellulose, magnesium stearate (vegetable source). Derived from fermented soy. Non-GMO. Gluten free. Vegan.

Quality and Trust

  • NPN 80135521 — Licensed by Health Canada as a Natural Health Product
  • Made in Canada — GMP certified facility under Health Canada oversight
  • 2,000 FU per capsule — Standardized to 20,000 FU/g for consistent enzymatic activity
  • Delayed release capsule — Protects enzyme from stomach acid | Intestinal delivery
  • Vegan capsule — Hypromellose shell, no gelatin or animal derived ingredients
  • Non-GMO and gluten free
  • 120 vegan capsules — 120 day supply at 1 capsule per day

Who This Is For

  • Adults seeking cardiovascular, vascular, and blood flow support from a standardized, delayed release nattokinase enzyme supplement
  • Those wanting a vegan nattokinase capsule with delayed release technology rather than a standard release capsule
  • Do not use if you are pregnant or breastfeeding, taking health products that affect blood coagulation, or have a bleeding disorder
  • Do not use if you have a soy allergy this product is derived from fermented soy
  • Consult a healthcare practitioner before use if you have a cardiovascular, kidney, or liver disorder, or are taking any medications
  • Stop use 7 days before any scheduled surgery, or immediately if you have unscheduled surgery or suffer an injury resulting in bruising or bleeding
  • For use beyond 4 weeks, consult a healthcare practitioner

How to Use

Adults: Take 1 capsule once per day, on an empty stomach or between meals, or as directed by a healthcare practitioner. Taking on an empty stomach maximizes intestinal delivery time. For use beyond 4 weeks, consult a healthcare practitioner.

Safety and Cautions

Contraindications: Do not use if pregnant or breastfeeding, taking health products that affect blood coagulation (anticoagulants, antiplatelet drugs), or if you have a bleeding disorder.

Warnings: This product is derived from fermented soy do not use if you have a soy allergy. Consult a healthcare practitioner before use if you have a cardiovascular, kidney, or liver disorder, or are taking any medications. Stop use 7 days before any scheduled surgery, or immediately if you have unscheduled surgery or suffer an injury resulting in bruising or bleeding. Keep out of reach of children.

NPN 80135521. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.

Nattokinase 2000 FU | Delayed Release | Cardiovascular & Vascular Health | 120 Vegan Capsules

$34.99

Health Canada Licensed Natural Health Product (NPN 80135521)

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Nattokinase 2000 FU | Delayed Release | Cardiovascular & Vascular Health | 120 Vegan Capsules

Each delayed release vegan capsule delivers 100mg of nattokinase providing 2,000 Fibrinolytic Units (FU) of enzymatic activity, standardized to 20,000 FU/g. Nattokinase is a serine protease enzyme produced during the fermentation of soybeans with Bacillus subtilis var. natto the same fermentation process used to produce natto, a traditional Japanese food consumed for over 1,000 years. Supports cardiovascular health, vascular health, and healthy blood flow.

Delayed release capsule technology protects the enzyme from stomach acid degradation, ensuring delivery to the intestines where absorption occurs. Health Canada licensed NPN 80135521. Vegan. Non-GMO. Gluten free. Made in Canada. 120 vegan capsules 120 day supply at 1 capsule per day.

Key Benefits

  • Supports cardiovascular health — Health Canada licensed claim under NPN 80135521
  • Supports vascular health — Health Canada licensed claim under NPN 80135521
  • Supports healthy blood flow — Health Canada licensed claim under NPN 80135521
  • 2,000 FU nattokinase per capsule — From 100mg nattokinase standardized to 20,000 FU/g
  • Delayed release capsule — Protects the enzyme from stomach acid | Delivers nattokinase intact to the intestines for optimal absorption
  • Serine protease enzyme — Produced by Bacillus subtilis var. natto fermentation of soybeans
  • Vegan capsule — Hypromellose delayed release shell, no gelatin or animal derived ingredients
  • Health Canada licensed — NPN 80135521 | GMP certified | Made in Canada
  • 120 vegan capsules — 120 day supply at 1 capsule per day

What Is Nattokinase?

Nattokinase is a serine protease enzyme produced during the fermentation of soybeans with Bacillus subtilis var. natto. It was first isolated and characterized by Dr. Hiroyuki Sumi in 1987 while researching natural fibrinolytic compounds. Natto the fermented soybean food from which nattokinase is derived has been consumed in Japan for over 1,000 years and is a traditional component of the Japanese diet.

Nattokinase enzymatic activity is measured in Fibrinolytic Units (FU), a standardized measure of the enzyme's proteolytic activity. This formula provides 2,000 FU per capsule from 100mg of nattokinase standardized to 20,000 FU/g a consistent, high-activity dose aligned with the clinical research literature.

Why Delayed Release Capsules Matter for Nattokinase

Nattokinase is a protein-based enzyme. Like all proteins, it is susceptible to denaturation and degradation in the highly acidic environment of the stomach (pH 1.5 to 3.5). Standard capsules release their contents immediately in the stomach, exposing the enzyme to acid before it can reach the intestines where absorption occurs.

Delayed release (enteric) capsules are engineered to remain intact in the acidic stomach environment and dissolve only when they reach the higher pH of the small intestine (pH 5.5 to 7.5). This protects the nattokinase enzyme from acid degradation and ensures delivery to the intestinal environment where it can be properly absorbed a critical distinction for enzyme supplements.

Understanding Fibrinolytic Units (FU)

FU (Fibrinolytic Units) is the standardized measure of nattokinase enzymatic activity. It quantifies the enzyme's ability to cleave fibrin the protein that forms the structural scaffold of blood clots. Higher FU indicates greater enzymatic activity per unit of enzyme. This formula provides:

  • Nattokinase per capsule: 100mg
  • Standardized potency: 20,000 FU/g
  • Activity per capsule: 2,000 FU
  • Daily dose: 1 capsule per day = 2,000 FU

Medicinal Ingredient (per capsule)

  • Nattokinase (Bacillus subtilis var. natto, whole) 100mg Standardized to 20,000 FU/g | 2,000 FU per capsule | Cardiovascular health | Vascular health | Healthy blood flow | NPN 80135521

Non-medicinal ingredients: Hypromellose (delayed release vegetable capsule shell), microcrystalline cellulose, magnesium stearate (vegetable source). Derived from fermented soy. Non-GMO. Gluten free. Vegan.

Quality and Trust

  • NPN 80135521 — Licensed by Health Canada as a Natural Health Product
  • Made in Canada — GMP certified facility under Health Canada oversight
  • 2,000 FU per capsule — Standardized to 20,000 FU/g for consistent enzymatic activity
  • Delayed release capsule — Protects enzyme from stomach acid | Intestinal delivery
  • Vegan capsule — Hypromellose shell, no gelatin or animal derived ingredients
  • Non-GMO and gluten free
  • 120 vegan capsules — 120 day supply at 1 capsule per day

Who This Is For

  • Adults seeking cardiovascular, vascular, and blood flow support from a standardized, delayed release nattokinase enzyme supplement
  • Those wanting a vegan nattokinase capsule with delayed release technology rather than a standard release capsule
  • Do not use if you are pregnant or breastfeeding, taking health products that affect blood coagulation, or have a bleeding disorder
  • Do not use if you have a soy allergy this product is derived from fermented soy
  • Consult a healthcare practitioner before use if you have a cardiovascular, kidney, or liver disorder, or are taking any medications
  • Stop use 7 days before any scheduled surgery, or immediately if you have unscheduled surgery or suffer an injury resulting in bruising or bleeding
  • For use beyond 4 weeks, consult a healthcare practitioner

How to Use

Adults: Take 1 capsule once per day, on an empty stomach or between meals, or as directed by a healthcare practitioner. Taking on an empty stomach maximizes intestinal delivery time. For use beyond 4 weeks, consult a healthcare practitioner.

Safety and Cautions

Contraindications: Do not use if pregnant or breastfeeding, taking health products that affect blood coagulation (anticoagulants, antiplatelet drugs), or if you have a bleeding disorder.

Warnings: This product is derived from fermented soy do not use if you have a soy allergy. Consult a healthcare practitioner before use if you have a cardiovascular, kidney, or liver disorder, or are taking any medications. Stop use 7 days before any scheduled surgery, or immediately if you have unscheduled surgery or suffer an injury resulting in bruising or bleeding. Keep out of reach of children.

NPN 80135521. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.

Supplement Facts

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 120

Ingredient
Amount Per
Serving
% Daily
Value
Nattokinase (Bacillus subtilis var. natto, whole) — 2,000 FU
100 mg
†

† Daily Value not established

Other Ingredients:
Hypromellose (Delayed Release Vegetable Capsule Shell), Microcrystalline Cellulose, Magnesium Stearate (Vegetable Source)

Clinical Research

Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects

Nutrition Research, 2009

This randomized, double blind, placebo controlled trial administered nattokinase supplementation to healthy human subjects and measured coagulation factors and blood flow markers over the study period. The study found that nattokinase significantly decreased plasma levels of fibrinogen, factor VII, and factor VIII key proteins involved in blood clot formation compared to placebo.

Nattokinase: a promising alternative in prevention and treatment of cardiovascular diseases

Biomarkers in Medicine, 2017

This comprehensive review examined the clinical and preclinical evidence for nattokinase in cardiovascular health. The review found that nattokinase exerts fibrinolytic activity by directly cleaving fibrin and activating endogenous plasminogen, supporting healthy blood flow and vascular function. The authors documented evidence for nattokinase's effects on blood pressure, blood viscosity, and vascular health markers across multiple human and animal studies

Effects of nattokinase on blood pressure: a randomized, controlled trial

Hypertension Research, 2008

This randomized, double blind, placebo controlled trial administered nattokinase to subjects with pre hypertension and stage 1 hypertension over 8 weeks and measured blood pressure and vascular health markers. The study found that nattokinase supplementation significantly reduced systolic and diastolic blood pressure compared to placebo, with the effect attributed to nattokinase's fibrinolytic activity and its effects on vascular tone and blood flow. The findings support nattokinase's role in cardiovascular and vascular health support

Research information is provided for educational purposes and does not replace the product's approved label information.

Frequently Asked Questions

What is nattokinase and what does it do?

Nattokinase is a serine protease enzyme produced during the fermentation of soybeans withBacillus subtilisvar.natto the same fermentation process used to produce natto, a traditional Japanese food consumed for over 1,000 years. Each delayed release capsule provides 100mg of nattokinase standardized to 20,000 FU/g, delivering 2,000 Fibrinolytic Units (FU) of enzymatic activity. Licensed by Health Canada to support cardiovascular health, vascular health, and healthy blood flow (NPN 80135521). Suitable for adults. For use beyond 4 weeks, consult a healthcare practitioner. Do not use if pregnant, breastfeeding, or taking anticoagulants.

What are Fibrinolytic Units (FU) and why do they matter?

Fibrinolytic Units (FU) is the standardized measure of nattokinase enzymatic activity quantifying the enzyme's ability to cleave fibrin, the protein that forms the structural scaffold of blood clots. Higher FU indicates greater enzymatic activity per capsule. This formula provides 2,000 FU per capsule from 100mg of nattokinase standardized to 20,000 FU/g a consistent, high-activity dose aligned with the clinical research literature on nattokinase. Licensed by Health Canada (NPN 80135521).

Why does nattokinase need delayed release capsules?

Nattokinase is a protein based enzyme susceptible to denaturation in the highly acidic stomach environment (pH 1.5 to 3.5). Standard capsules release their contents immediately in the stomach, exposing the enzyme to acid before it can reach the intestines where absorption occurs. Delayed release (enteric) capsules remain intact in the acidic stomach and dissolve only in the higher pH of the small intestine (pH 5.5 to 7.5) protecting the enzyme from acid degradation and ensuring delivery to the intestinal environment for optimal absorption. This is a critical distinction for enzyme supplements.

How does nattokinase support cardiovascular health?

Nattokinase is a serine protease enzyme with fibrinolytic activity it cleaves fibrin, the protein scaffold of blood clots. It has been studied for its effects on blood flow, vascular function, and cardiovascular health markers. Licensed by Health Canada to support cardiovascular health, vascular health, and healthy blood flow. Consult a healthcare practitioner before use if you have a cardiovascular disorder or are taking any medications. Do not use if taking anticoagulants or antiplatelet drugs.

Should I take nattokinase with food or on an empty stomach?

Take 1 capsule on an empty stomach or between meals. Taking on an empty stomach maximizes intestinal transit time and reduces competition from dietary proteins for enzymatic activity. The delayed release capsule protects the enzyme from stomach acid regardless of food intake, but taking between meals is generally recommended for enzyme supplements. For use beyond 4 weeks, consult a healthcare practitioner.

Can I take nattokinase if I am on blood thinners?

No. Do not use if you are taking health products that affect blood coagulation including anticoagulants such as warfarin or antiplatelet drugs. Nattokinase has fibrinolytic enzymatic activity and may enhance the effects of blood thinning medications, increasing the risk of bleeding. Consult a healthcare practitioner before use if you have a cardiovascular disorder or are taking any medications. Stop use 7 days before any scheduled surgery.

Who should not take nattokinase?

Do not use if you are pregnant or breastfeeding, taking health products that affect blood coagulation (anticoagulants, antiplatelet drugs), or have a bleeding disorder. Do not use if you have a soy allergy this product is derived from fermented soy (Bacillus subtilisvar.natto). Stop use 7 days before any scheduled surgery, or immediately if you have unscheduled surgery or suffer an injury resulting in bruising or bleeding. Consult a healthcare practitioner before use if you have a cardiovascular, kidney, or liver disorder.

Does nattokinase contain soy or allergens?

Yes. Nattokinase is derived from the fermentation of soybeans withBacillus subtilisvar.natto. Do not use if you have a soy allergy. The capsule shell is vegan hypromellose no gelatin. Non-medicinal ingredients: Hypromellose (Delayed Release Vegetable Capsule Shell), Microcrystalline Cellulose, Magnesium Stearate (Vegetable Source). Non-GMO. Gluten free. Suitable for vegans and vegetarians with no soy allergy.

Canadian-Made

Lab-Tested

Health Canada Approved

20 Years of Research

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