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NMN 500 mg supplement NAD precursor 60 vegan capsules
NMN 500 mg Nicotinamide Mononucleotide NAD+ Precursor, 60 Vcaps
High-Potency NMN 500 mg Supplement for Cellular Energy and Longevity
Nicotinamide Mononucleotide 500 mg for NAD+ and Healthy Aging Support
NMN Supplement for Cellular Energy, Metabolism and Longevity Support
NMN 500 mg NAD+ Precursor Formula for Healthy Aging and Vitality
NMN 500 mg supplement facts label 60 capsules
NMN 500 mg supplement NAD precursor 60 vegan capsules

NAD+ is a coenzyme essential to energy production, DNA repair, and cellular regulation. Its levels decline by roughly 50% between young adulthood and middle age. NMN (nicotinamide mononucleotide) is the most direct NAD+ precursor available one biosynthetic step from NAD+, and the most studied route to raising NAD+ levels in human clinical research.

How NMN Works

NMN is converted directly to NAD+ by a single enzyme (NMNAT), without the additional conversion steps required by niacin or nicotinamide. Human studies at 250 mg to 1,200 mg per day consistently show measurable increases in blood NAD+ within hours of dosing. The 500 mg dose in this formula sits within the range most studied for effects on energy metabolism, muscle insulin sensitivity, and physical performance.

NAD+ is the required substrate for sirtuins (SIRT1–SIRT7) the proteins that regulate DNA repair, gene expression, and metabolic adaptation and for PARP enzymes, which use NAD+ to coordinate cellular DNA repair. Maintaining NAD+ levels supports both pathways. Unlike NMN resveratrol combinations, this is a pure NMN supplement designed to address NAD+ availability directly at the source.

NMN 500mg | Nicotinamide Mononucleotide | NAD+ Precursor | Cellular Energy and Longevity

$48.85
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Health Canada Licensed Natural Health Product (NPN 80132879)

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NAD+ is a coenzyme essential to energy production, DNA repair, and cellular regulation. Its levels decline by roughly 50% between young adulthood and middle age. NMN (nicotinamide mononucleotide) is the most direct NAD+ precursor available one biosynthetic step from NAD+, and the most studied route to raising NAD+ levels in human clinical research.

How NMN Works

NMN is converted directly to NAD+ by a single enzyme (NMNAT), without the additional conversion steps required by niacin or nicotinamide. Human studies at 250 mg to 1,200 mg per day consistently show measurable increases in blood NAD+ within hours of dosing. The 500 mg dose in this formula sits within the range most studied for effects on energy metabolism, muscle insulin sensitivity, and physical performance.

NAD+ is the required substrate for sirtuins (SIRT1–SIRT7) the proteins that regulate DNA repair, gene expression, and metabolic adaptation and for PARP enzymes, which use NAD+ to coordinate cellular DNA repair. Maintaining NAD+ levels supports both pathways. Unlike NMN resveratrol combinations, this is a pure NMN supplement designed to address NAD+ availability directly at the source.

Supplement Facts

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 60

Ingredient
Amount Per
Serving
% Daily
Value
Nicotinamide Mononucleotide (NMN)
500 mg
†

† Daily Value not established

Other Ingredients:
Hypromellose (Vegetable Capsule Shell), Microcrystalline Cellulose, Silicon Dioxide

Clinical Research

Nicotinamide mononucleotide (NMN) supplementation increases blood NAD+ levels in healthy adults: a randomized, double blind, placebo controlled trial

npj Aging and Mechanisms of Disease, 2022

This randomized, double blind, placebo controlled trial administered oral NMN (250mg daily) to healthy adults aged 65 and older and measured blood NAD+ levels and metabolic markers over 12 weeks. The study found that NMN supplementation significantly increased blood NAD+ levels compared to placebo, with increases detectable within the first week of supplementation. The authors also observed improvements in muscle insulin sensitivity and physical performance markers, and concluded that oral NMN is an effective and well tolerated NAD+ precursor in older adults.

Oral administration of nicotinamide mononucleotide is safe and efficiently increases blood nicotinamide adenine dinucleotide levels in healthy subjects

Frontiers in Nutrition, 2022

This clinical study examined the safety and pharmacokinetics of oral NMN supplementation at doses of 300mg, 600mg, and 900mg per day in healthy adults. The study found that all doses significantly increased blood NAD+ levels in a dose-dependent manner, with no serious adverse events reported at any dose. The authors confirmed that oral NMN is efficiently absorbed and converted to NAD+ in humans, and that 500mg per day falls within the safe and effective dose range studied.

NAD+ metabolism and its roles in cellular processes during ageing

Nature Reviews Molecular Cell Biology, 2021

This comprehensive review examined the role of NAD+ in cellular aging, documenting the mechanisms of age related NAD+ decline (PARP activation, CD38 upregulation, reduced biosynthesis) and the downstream consequences for mitochondrial function, sirtuin activity, DNA repair, and metabolic health. The review confirmed that NMN is the most direct NAD+ precursor available for supplementation and that restoring NAD+ levels through NMN supplementation supports the cellular energy, repair, and regulatory pathways that decline with age related NAD+ depletion.

Research information is provided for educational purposes and does not replace the product's approved label information.

Frequently Asked Questions

What is NMN and what is it used for?

NMN (nicotinamide mononucleotide) is a naturally occurring nucleotide and the immediate biosynthetic precursor to NAD+ (nicotinamide adenine dinucleotide) a coenzyme found in every living cell that is essential for cellular energy production, DNA repair, and the regulation of hundreds of metabolic processes. NMN supplementation supports NAD+ biosynthesis, helping to maintain the NAD+ levels needed for healthy cellular function. Consult a healthcare practitioner before use if you are pregnant, breastfeeding, or have a history of cancer or are undergoing cancer treatment.

What is NAD+ and why does it decline with age?

NAD+ is a coenzyme that participates in over 500 enzymatic reactions in the human body, including cellular energy production, DNA repair, and sirtuin mediated gene regulation. Despite its fundamental importance, NAD+ levels decline by approximately 50% between young adulthood and middle age. This decline is driven by increased NAD+ consumption by PARP enzymes responding to accumulated DNA damage, by CD38 (an NAD+ consuming enzyme that increases with age), and by reduced biosynthesis capacity. Age related NAD+ depletion is now recognized as a central mechanism in the biology of aging.

How does NMN raise NAD+ levels?

NMN is converted directly to NAD+ by the enzyme NMNAT (nicotinamide mononucleotide adenylyltransferase) in the Preiss Handler biosynthesis pathway. Because NMN is one biosynthetic step from NAD+, it is one of the most direct and efficient routes to raising cellular NAD+ levels. Human clinical studies have shown significant increases in blood NAD+ levels within hours of oral NMN supplementation. NMN is more direct than other NAD+ precursors such as niacin or nicotinamide, which require additional biosynthetic steps before conversion to NAD+.

How does NAD+ support cellular energy production?

NAD+ is the primary electron carrier in oxidative phosphorylation the mitochondrial process that produces ATP (the cell's energy currency). NAD+ accepts electrons from metabolic substrates and transfers them to the mitochondrial electron transport chain, driving ATP synthesis. Without adequate NAD+, mitochondrial energy production is impaired, reducing the cell's capacity to generate ATP and perform energy dependent functions. NMN supports NAD+ biosynthesis, helping to maintain mitochondrial function and energy production capacity across high demand tissues including muscle, brain, liver, and heart.

How does NMN support DNA repair?

PARP (poly ADP ribose polymerase) enzymes are the primary DNA repair enzymes in human cells. They consume NAD+ to synthesize poly ADP ribose chains that coordinate the DNA strand break repair response. As DNA damage accumulates with age, PARP activity increases, consuming more NAD+ and accelerating NAD+ depletion. Maintaining NAD+ substrate availability through NMN supplementation supports healthy PARP mediated DNA repair activity and genomic integrity.

Who should not take NMN?

Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a history of cancer or are undergoing cancer treatment (NAD+ supports cellular proliferation pathways and implications for cancer biology are an active area of research), or are taking medications that affect NAD+ metabolism. Keep out of reach of children.

Canadian-Made

Lab-Tested

Health Canada Approved

20 Years of Research

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