GABA 750mg | Gamma Aminobutyric Acid | Fermentation Derived | 90 Vcaps

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. It is synthesized in the brain from glutamate via the enzyme glutamate decarboxylase and acts by binding to GABA-A and GABA-B receptors on neurons, reducing neuronal excitability. GABA plays a central role in regulating the balance between excitatory and inhibitory signalling a balance that underlies cognitive function, stress response, muscle tone, and nervous system tone.

The GABA in this formula is produced by microbial fermentation the same biosynthetic process used to produce pharmaceutical-grade amino acids and vitamins. In fermentation, microorganisms convert a substrate (typically glucose or glutamate) into GABA via enzymatic activity. The resulting GABA is chemically identical to the GABA produced endogenously in the brain. It is not derived from animal sources and is suitable for vegans and vegetarians.

This is an active area of scientific discussion. GABA is a large, polar molecule, and the classical view held that it could not cross the blood-brain barrier (BBB) in meaningful amounts. More recent research has proposed that orally administered GABA may influence the nervous system through peripheral mechanisms including effects on the enteric nervous system and the gut brain axis and that some transport across the BBB may occur under certain conditions. The clinical evidence for orally supplemented GABA's effects continues to be evaluated.

Both GABA and alcohol act on the GABAergic system alcohol enhances GABA-A receptor activity, producing inhibitory effects on the central nervous system. Combining GABA supplementation with alcohol may produce additive CNS depressant effects. Avoid use with alcohol as directed on the Health Canada licensed label (NPN 80139642).