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The Enzyme Showdown: Bromelain vs. Serrapeptase

The Enzyme Showdown: Bromelain vs. Serrapeptase

Enzymes are nature’s little miracles, catalyzing crucial biochemical reactions in our bodies. Among the myriad of enzymes available as supplements, two have caught the attention of the health-conscious public: Bromelain from pineapple stems and Serrapeptase from the silkworm.

What is Bromelain 2,400GDU?

Bromelain is a proteolytic enzyme found in pineapples, particularly concentrated in the stem. The potency of bromelain supplements is measured in Gelatin Digesting Units (GDU) per gram. A 2400GDU rating indicates a high potency enzyme capable of digesting a substantial amount of protein. Bromelain is celebrated for its anti-inflammatory properties, making it popular for treating conditions such as sinusitis, arthritis, and post-operative swelling.


What is Serrapeptase 12,000SPU?

Serrapeptase, a protease produced by the Serratia bacteria within the silkworm, is used by the worm to dissolve its cocoon. Measured in Serratiopeptidase Units (SPU), Serrapeptase has a 12000SPU rating, denoting a very high enzyme activity level. This enzyme has been used in Europe and Asia for its ability to reduce inflammation and pain, and to break down mucus and dead tissue.

Comparing the Benefits

Both enzymes are known for their anti-inflammatory effects, but their uses vary slightly:

  • Bromelain 2,400 GDU: Studies suggest that it may enhance the absorption of antibiotics, reduce inflammation, inhibit tumor growth, and improve digestion of proteins.
  • Serrapeptase 12,000 SPU: It is used for reducing pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and carpal tunnel syndrome. It also helps in reducing mucus build-up and promoting wound healing.

Efficacy in Pain and Inflammation

When it comes to pain and inflammation, both enzymes show promising results. Bromelain's efficacy in reducing osteoarthritis pain is comparable to some anti-inflammatory medications. Serrapeptase is noted for its ability to reduce inflammation and pain, with some studies suggesting its efficacy could rival that of NSAIDs.

Side Effects and Considerations

Both enzymes are generally considered safe, but they can have side effects. Bromelain may cause gastrointestinal discomfort or allergic reactions, especially for those allergic to pineapples. Serrapeptase may also cause gastrointestinal issues and is not recommended for those on blood thinners or who have bleeding disorders.

Dosage and Supplement Forms

Bromelain is often taken between meals to maximize its anti-inflammatory effects, while Serrapeptase is typically taken on an empty stomach to allow the enzyme to enter the bloodstream more easily.


Bromelain and Serrapeptase are powerful enzymes each with unique benefits. Bromelain from pineapple stems offers a natural way to fight inflammation and aid digestion, while Serrapeptase from the silkworm provides a potent tool for reducing pain and inflammation. When choosing between them, consider the specific health benefits you seek, any potential side effects, and how they may interact with other medications or supplements you’re taking. As always, consult with a healthcare provider before starting any new supplement regimen.

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